Determination the CTLA-4 and PTPN22 Gene Polymorphism in Graves’ Disease Patients

Graves’ disease (GD) is a multifactorial autoimmune with contribution from both genetic andepigenetic factors in its causation. Gene “protein tyrosine phosphatase non receptor 22” (PTPN22) animportant immune regulatory gene preventing hyper responsiveness of T cells by negatively regulatingtheir signal transduction. Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) polymorphisms belong to themain determining the susceptibility development disease. This study aimed toanalyze whether 1858 C/T SNP PTPN22 and 1822 CLTA-4 genes have any association withGD Iraqi population. PCR-RFLP was performed for genotyping withinPTPN22 respectively, patients GD healthy controls. Among GD,the frequencies CC, CT, TT genotypes were 43.3%, 45%, 11.6%, whereas inhealthy controls CT 60%, 30%, 10%, respectively. While thereis no mutation recorded DNA sequence analysis. Theseresults indicated that there significant found between andCLTA-4 GD. It has been concluded not associated SNPand